sate slotThe second M.2 slot usually does run through the chipset, which is also where the SATA controller for ports >5 usually does reside. And sometimes yes using the lower M.2 will disableSATA Express slots are a type of SATA slot that combines the SATA and PCIe interfaces. They offer data transfer rates of up to 16 Gbps and are desned for use with hh